Author

A. Varki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

H. Yu· 3 shared X. Chen· 3 shared A. Sasmal· 2 shared S. Saha· 2 shared A. D. Cox· 1 shared A. Verhagen· 1 shared B. K. Alford-Lawrence· 1 shared B. R. Wasik· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

H. Yu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Evolution of Human-specific Alleles Protecting Cognitive Function of Grandmothers

S. Saha, N. Khan, T. Comi, A. Verhagen, A. Sasmal, S. Diaz, H. Yu, X. Chen, J. M. Akey, M. Frank, P. Gagneux, A. Varki

The paper investigates human-specific CD33 mutations linked to cognitive protection and Alzheimer's disease resistance, linking them to evolutionary pressures and immune evasion.

bioRxiv · Nov 26, 2021Evolutionary Biology

Acidosis, Zinc and HMGB1 in Sepsis: A Common Connection Involving Sialoglycan Recognition

S. S. Siddiqui, C. Dhar, V. Sundaramurthy, A. Sasmal, H. Yu, E. Bandala-Sanchez, M. Li, X. Zhang, X. Chen, L. C. Harrison, D. Xu, A. Varki

This study shows that HMGB1 is sequestered by plasma sialoglycoproteins at physiological pH but is released during sepsis when pH and zinc levels drop, leading to immune activation.

Proceedings of the National Academy of Sciences · Mar 3, 2021Peer-reviewedImmunology

The effects of modified sialic acids on mucus and erythrocytes on influenza A virus HA and NA functions

K. N. Barnard, B. K. Alford-Lawrence, D. W. Buchholz, B. R. Wasik, J. R. LaClair, H. Yu, R. Honce, S. Ruhl, P. Pajic, E. K. Daugherity, X. Chen, S. Schultz-Cherry, H. C. Aguilar, A. Varki, C. R. Parrish

This study examines how modified sialic acids in mucus and erythrocytes affect influenza A virus HA and NA functions, finding that these modifications inhibit viral binding and cleavage.

bioRxiv · Oct 10, 2019 · PreprintMicrobiology

A novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide links heptose II lactose expression with pathogenicity

S. Ram, S. Gulati, L. A. Lewis, S. Chakraborti, B. Zheng, R. B. DeOliveira, G. W. Reed, A. D. Cox, J. Li, F. St. Michael, J. Stupak, X.-H. Su, S. Saha, C. S. Landig, A. Varki, P. A. RICE

This paper identifies a novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide that links HepII lactose expression with pathogenicity and vaccine potential.

bioRxiv · Apr 17, 2018Microbiology