K. Yamamoto

Metabolic and imaging phenotypes associated with RB1 and TP53 loss in prostate cancer

This study investigates metabolic and imaging phenotypes in prostate cancer linked to RB1 and TP53 loss, finding metabolic changes that may inform multimodal imaging strategies.

Evofosfamide and Gemcitabine Act Synergistically in Pancreatic Cancer Xenografts by Dual Action on Tumor Vasculature and Inhibition of Homologous Recombination DNA Repair

This study shows that evofosfamide and gemcitabine work together in pancreatic cancer xenografts by improving tumor oxygenation and inhibiting DNA repair, with effects varying by tumor type.

Microscopic and metatranscriptomic analyses revealed unique cross-domain symbiosis between Candidatus Patescibacteria/candidate phyla radiation (CPR) and methanogenic archaea in anaerobic ecosystems

The paper investigates the interaction between Candidatus Patescibacteria and methanogenic archaea using microscopy and metatranscriptomic analyses, concluding a parasitic relationship.

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmunity

This study shows that upregulated Fcrl5 disrupts B cell anergy, leading to autoimmunity by activating autoreactive B cells and exacerbating autoimmune disease models.

Conformational features and interaction mechanisms of VHH antibodies with β-hairpin-like CDR-H3: A case of Nb8-HigB2 interaction.

This study investigates the conformational features and interaction mechanisms of a β-hairpin-like CDR-H3 in the VHH antibody Nb8, revealing key residues critical for structural stability and binding to HigB2.

Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia

The paper identifies lineage-specific therapeutic vulnerabilities in AML subtypes using a two-group comparison approach based on genetic data from the Cancer Dependency Map.

Evaluation of a deuterated triarylmethyl spin probe for in vivo R2*-based EPR oximetric imaging with enhanced dynamic range

This study compares two spin probes for oxygen measurement in vivo, finding Ox071 more sensitive and capable of a broader pO2 range.

Vascular Endothelial Cells Perform Distinct Sensing and Signaling of Laminar and Disturbed Flows across Plasma Membranes and Mitochondria

This study shows vascular endothelial cells sense laminar and disturbed flows through changes in plasma and mitochondrial membrane lipid order, leading to distinct mitochondrial responses.

Spatiotemporal mapping of the contractile and adhesive forces sculpting early C. elegans embryos

This study maps spatiotemporal changes in cellular tensions during early C. elegans embryo development using a hybrid inference pipeline validated with AFM and live microscopy.

Taxonomic difference in marine bloom-forming phytoplanktonic species affects dynamics of both bloom-responding prokaryotes and prokaryotic viruses

This study shows that different phytoplankton species affect the dynamics of prokaryotes and their viruses during blooms.

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

This study shows that African-lineage ZIKV infection in early first trimester causes high pregnancy loss in rhesus macaques, regardless of SIV status.

Indirect CRISPR screening with photoconversion revealed key factors of drug resistance with cell-cell interactions

This study uses indirect CRISPR screening with photoconversion to identify key factors of drug resistance mediated by cell-cell interactions, finding genes that reduce cancer cell apoptosis when knocked out in supporting cells.

Single-cell multi-omics enabled discovery of alkaloid biosynthetic pathway genes in the medical plant Catharanthus roseus

The paper uses single-cell multi-omics to identify alkaloid biosynthesis genes in Catharanthus roseus, revealing gene clusters, paralogs, and cell-type specific expression patterns.

Symbiosis between Patescibacteria and Archaea discovered in wastewater-treating bioreactors

The paper discovers a cross-domain symbiosis between Patescibacteria and methanogenic archaea in wastewater treatment bioreactors using microscopy and FISH.

Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus

This study shows that high-dose African-lineage Zika virus infection in late first trimester pregnant rhesus macaques causes frequent fetal loss.

Uncovering the ligandome of low-density lipoprotein receptor-related protein 1 in cartilage: a top-down approach to identify therapeutic targets

This study identifies the ligandome of LRP1 in cartilage using a top-down approach, revealing novel ligands and their role in osteoarthritis.

Aberrant mechanosensitive signaling underlies activation of vascular endothelial xanthine oxidoreductase that promotes aortic aneurysm formation in Marfan syndrome

This study identifies aberrant mechanosensitive signaling in vascular endothelial cells as a driver of xanthine oxidoreductase activation and ROS generation, contributing to aortic aneurysm formation in Marfan syndrome.

PEGPH20, a PEGylated Human Hyaluronidase, Induces Radiosensitization by Reoxygenation In Pancreatic Cancer Xenografts. A Molecular Imaging Study

This study shows PEGPH20 improves radiation therapy efficacy in pancreatic cancer tumors with high hyaluronan by increasing oxygenation, as measured by multiple imaging techniques.

The dgc2 gene encoding di-guanylate cyclase suppresses both motility and biofilm formation in the filamentous cyanobacterium Leptolyngbya boryana.

This study identifies the dgc2 gene in Leptolyngbya boryana, showing that its inactivation suppresses motility and enhances biofilm formation, revealing a novel role for c-di-GMP in colony pattern formation.

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

This study develops a bulk differentiation method for MYOD1-hiPSCs to generate contractile skeletal muscles, improving efficiency and reducing clonal variation compared to clonal methods.

Autotaxin is a Potential Link between Genetic Risk Factors and Pathogenesis of Systematic Lupus Erythematosus in Plasmacytoid Dendritic Cells

The paper investigates autotaxin's role in SLE by analyzing transcriptome and eQTL data, finding elevated autotaxin levels and its association with interferon-related genes in pDCs.

Immune cell multi-omics analysis reveals contribution of oxidative phosphorylation to B cell functions and organ damage of lupus

The paper identifies oxidative phosphorylation (OXPHOS) as a key driver in SLE B cells, linking mitochondrial dysfunction to immune signaling and organ damage.

Prevalence of viral frequency-dependent infection in coastal marine prokaryotes revealed using monthly time series virome analysis

The paper analyzes monthly virome and 16S rRNA data from Osaka Bay to show frequency-dependent viral infection in marine prokaryotes, regardless of host growth strategy.

Detecting Early Response to Immune Checkpoint Blockade by Multimodal Molecular Imaging

This study uses multimodal imaging to detect early response to immune checkpoint blockade therapy in tumor models, identifying imaging biomarkers for treatment assessment.

Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

The paper introduces OptoMYPT, an optogenetic tool to relax actomyosin contractility, revealing cortical tension's role in cytokinesis by accelerating furrow ingression.

CRISPR-Targeted CAR Gene Insertion Using Cas9/RNP and AAV6 Enhances Anti-AML Activity of Primary NK Cells

Heterogeneous strains in tissue collagen show that high strains locally suppress degradation by collagenase

This paper investigates how mechanical strain affects collagen degradation in tendon and heart tissues, finding that moderate strains suppress degradation while higher strains do not.

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

Compartmentalized three-dimensional human neuromuscular tissue models fabricated on a well-plate-format microdevice

This study develops a microdevice for compartmentalized coculturing of motor neurons and skeletal muscle tissues to form functional neuromuscular junctions and test drug responses.

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques

This study infects pregnant rhesus macaques with African- and Asian-lineage Zika virus to compare their pathogenesis, finding similar replication kinetics but higher viral burden in maternal-fetal interface tissues with African-lineage isolates.