C. E. M. Stevenson

Resurrection of plant disease resistance proteins via helper NLR bioengineering

A helper NLR is mutated to evade inhibition by a parasite effector, restoring disease resistance gene activity.

Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism

The paper reports the crystal structure of an ADH enzyme that catalyzes a non-canonical 1,4 reduction, providing insights into how plant ADHs diversify their catalytic functions.

Genome-wide identification of the LexA-mediated DNA damage response in Streptomyces venezuelae

This study identifies the LexA-mediated DNA damage response in Streptomyces venezuelae using transcriptional profiling and ChIP-seq, revealing the regulon and DNA repair gene regulation.

A CTP-dependent gating mechanism enables ParB spreading on DNA

This study identifies a CTP-dependent gating mechanism in ParB that regulates its nucleation, spreading, and recycling during chromosome segregation in Caulobacter crescentus.

CTP regulates membrane-binding activity of the nucleoid occlusion protein Noc

This study shows that CTP regulates the membrane-binding activity of the nucleoid occlusion protein Noc in Bacillus subtilis by controlling its ability to form nucleoprotein complexes.

Two NLR immune receptors acquired high-affinity binding to a fungal effector through convergent evolution of their integrated domain

The paper reconstructs the evolutionary history of rice NLR receptors Pik-1 and Pik-2, showing their HMA domain evolved convergent high-affinity binding to the fungal effector AVR-PikD.

Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides

This study uses AFM and MD simulations to analyze how DNA supercoiling affects structure and triplex-forming oligonucleotide binding at base-pair resolution.