Tolerance to the antifungal drug fluconazole is mediated by tuning cytoplasmic fluidity
E. Plumb, Antonio Serrano, L. Chevalier, Johannes Elferich, Ludwig Roman Sinn, Nikolaus Grigorieff, Markus Ralser, Judith G. Berman, Martine Bassilana, Robert Alan Arkowitz
This study shows that fluconazole tolerance in fungi is linked to decreased cytoplasmic fluidity and increased heterogeneity, mediated by changes in ribosome dynamics and P-body formation.
bioRxiv · Dec 3, 2025 · PreprintMicrobiology