Author

S. A. Isaacson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Allard· 2 shared J. Goyette· 2 shared O. Dushek· 2 shared C. A. Larabell· 1 shared C. S. Peskin· 1 shared D. Depoil· 1 shared J. Ma· 1 shared K. Gaus· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

J. Allard

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3 papers

Recent·Most cited

Strong intracellular signal inactivation produces sharper and more robust signaling from cell membrane to nucleus

J. Ma, M. Do, M. A. Le Gros, C. S. Peskin, C. A. Larabell, Y. Mori, S. A. Isaacson

The paper models how signal inactivation sharpens and stabilizes chemical signal propagation through the cytosol by filtering non-geodesic paths in human B cells.

PLOS Computational Biology · Nov 16, 2020Peer-reviewedBiophysics

Regulated unbinding of ZAP70 at the T cell receptor by kinetic avidity

J. Goyette, D. Depoil, Z. Yang, S. A. Isaacson, J. Allard, P. A. van der Merwe, K. Gaus, M. Dustin, O. Dushek

The paper shows that ZAP70 unbinding from TCR is regulated by kinetic avidity, allowing both signal fidelity and reversibility in T cell responses.

bioRxiv · Feb 12, 2020 · PreprintImmunology

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions

Y. Zhang, L. Clemens, J. Goyette, J. Allard, O. Dushek, S. A. Isaacson

The paper studies how molecular reach and diffusivity affect reaction efficacy in membrane-confined systems, showing that increasing reach can enhance or reduce efficacy depending on diffusion rates.

bioRxiv · Apr 7, 2019Biophysics