Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion
C. M. Le Gall, A. Cammarata, L. de Haas, I. Ramos-Tomillero, J. Cuenca-Escalona, Z. Wijfjes, A. M. D. Becker, Y. Dolen, I. J. M. de Vries, C. G. Figdor, G. Florez-Grau, M. Verdoes
This study demonstrates that targeting NY-ESO-1 antigen to human cDC1s via XCL1(CC3) enhances cross-presentation and CD8+ T cell activation.
bioRxiv · Nov 30, 2021Immunology