Author

C. M. Le Gall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. G. Figdor· 3 shared M. Verdoes· 3 shared A. Cammarata· 2 shared A. M. D. Becker· 2 shared D. van Dalen· 2 shared F. A. Scheeren· 2 shared I. Ramos-Tomillero· 2 shared Y. Dolen· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersImmunology

C. G. Figdor

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Efficient targeting of NY-ESO-1 tumor antigen to human cDC1s by lymphotactin results in cross-presentation and antigen-specific T cell expansion

C. M. Le Gall, A. Cammarata, L. de Haas, I. Ramos-Tomillero, J. Cuenca-Escalona, Z. Wijfjes, A. M. D. Becker, Y. Dolen, I. J. M. de Vries, C. G. Figdor, G. Florez-Grau, M. Verdoes

This study demonstrates that targeting NY-ESO-1 antigen to human cDC1s via XCL1(CC3) enhances cross-presentation and CD8+ T cell activation.

bioRxiv · Nov 30, 2021Immunology

Dual site-specific chemoenzymatic antibody fragment conjugation using CRISPR-based hybridoma engineering

C. M. Le Gall, J. M. van der Schoot, I. Ramos-Tomillero, M. Parlak Khalily, F. J. van Dalen, Z. Wijfjes, L. Smeding, D. van Dalen, A. Cammarata, K. M. Bonger, C. G. Figdor, F. A. Scheeren, M. Verdoes

This paper introduces a CRISPR-based method to engineer hybridoma cells that secrete dual-tagged Fab fragments, enabling site-specific conjugation of multiple cargos.

bioRxiv · Dec 8, 2020Biochemistry

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

J. M. S. van der Schoot, F. L. Fennemann, M. Valente, Y. Dolen, I. M. Hagemans, A. M. D. Becker, C. M. Le Gall, D. van Dalen, A. Cevirgel, J. A. C. van Bruggen, M. Engelfriet, M. F. Fransen, T. Caval, A. E. H. Bentlage, M. Nederend, , F. A. Scheeren

This study presents a CRISPR/HDR platform to engineer hybridoma antibodies for diverse isotypes, formats, and species, enabling functional antibody diversification.

bioRxiv · Feb 15, 2019Bioengineering