Author

L. de Koning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Research Focus:differential expression· 4 Organism:human· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Organism:bacteria (other)· 2

Frequent Co-Authors

A. Cartier· 3 shared B. Ouine· 3 shared A. Byron· 2 shared B. Serrels· 2 shared B. Swarge· 2 shared C. de Koster· 2 shared K. G. Macleod· 2 shared N. O. Carragher· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

A. Cartier

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP signaling in dormant disseminated uveal melanoma

R. Kadamb, M. L. Anton, T. J. Purwin, L. Seeneevassen, V. Chua, F. Waltrich, J. Teh, M. A. Nieto, T. Sato, M. Terai, S. Roman, L. de Koning, D. Zheng, A. E. Aplin, J. Aguirre-Ghiso

This study identifies NR2F1 as a key regulator of dormancy in uveal melanoma by epigenetically suppressing oncogenic Gαq/11-YAP signaling and cell cycle genes.

bioRxiv · Mar 5, 2024 · PreprintCancer Biology

Multicenter reverse-phase protein array data integration

L. de Koning, S. Bernhardt, K. G. Macleod, B. Ouine, A. Cartier, V. Sibut, N. O. Carragher, U. Korf, B. Serrels, A. Byron

This paper integrates multicenter reverse-phase protein array data from breast cancer cell responses to two drugs, quantifying 86,832 spots across three platforms to create a public resource for comparing RPPA workflows.

bioRxiv · Aug 31, 2021 · PreprintBiochemistry

Proliferation genes repressed by TGF-β are downstream of Slug/Snail2 in normal bronchial epithelial progenitors and are deregulated in COPD

C. Ben Brahim, C. Courageux, A. Jolly, B. Ouine, A. Cartier, P. de la Grange, L. de Koning, P. Leroy

The paper investigates Slug/Snail2 downstream genes in bronchial epithelial progenitors, showing differences in proliferation gene repression between normal and COPD cells.

bioRxiv · Sep 3, 2020Cell Biology

Integrative analysis of multi-platform reverse-phase protein array data for the pharmacodynamic assessment of response to targeted therapies

A. Byron, S. Bernhardt, B. Ouine, A. Cartier, K. G. Macleod, N. O. Carragher, V. Sibut, U. Korf, B. Serrels, L. de Koning

The paper assesses variability between RPPA platforms and identifies consistent protein expression and phosphorylation signatures across different platforms and workflows.

bioRxiv · Sep 16, 2019Cancer Biology

Integrative analysis of proteome and transcriptome dynamics during Bacillus subtilis spore revival

B. Swarge, M. Jonker, W. Abhyankar, H. Hoefsloot, C. de Koster, S. Brul, L. de Koning

This study analyzes transcriptome and proteome changes during Bacillus subtilis spore germination and outgrowth, identifying key transcripts and proteins involved in the process.

bioRxiv · Jun 26, 2019Microbiology

Towards the minimal proteome of life: Proteome profiles of Bacillus subtilis vegetative cells and spores

B. Swarge, W. Roseboom, C. de Koster, S. Brul, L. de Koning

This study quantifies protein levels in Bacillus subtilis vegetative cells and spores using 15N metabolic labeling, revealing 60% shared proteins essential for spore survival and germination.

bioRxiv · Jun 21, 2019 · PreprintMicrobiology