Author

T. J. Purwin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. E. Aplin· 2 shared C. Del Casale· 1 shared C. M. Snyder· 1 shared D. Zheng· 1 shared F. Waltrich· 1 shared J. Aguirre-Ghiso· 1 shared J. Teh· 1 shared L. de Koning· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

A. E. Aplin

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2 papers

Recent·Most cited

Lineage commitment pathways epigenetically oppose oncogenic Gαq/11-YAP signaling in dormant disseminated uveal melanoma

R. Kadamb, M. L. Anton, T. J. Purwin, L. Seeneevassen, V. Chua, F. Waltrich, J. Teh, M. A. Nieto, T. Sato, M. Terai, S. Roman, L. de Koning, D. Zheng, A. E. Aplin, J. Aguirre-Ghiso

This study identifies NR2F1 as a key regulator of dormancy in uveal melanoma by epigenetically suppressing oncogenic Gαq/11-YAP signaling and cell cycle genes.

bioRxiv · Mar 5, 2024 · PreprintCancer Biology

Murine cytomegalovirus infection of melanoma lesions delays tumor growth by recruiting and re-polarizing monocytic phagocytes in the tumor

N. A. Wilski, C. Del Casale, T. J. Purwin, A. E. Aplin, C. M. Snyder

This paper shows that murine cytomegalovirus (MCMV) delays melanoma tumor growth by recruiting and re-polarizing monocytic phagocytes, with viral chemokine MCK2 playing a key role.

bioRxiv · Apr 6, 2019Immunology