Author

L. Denby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. Cairns· 2 shared D. Ferenbach· 2 shared E. D. O'Sullivan· 2 shared J. Hughes· 2 shared N. C. Henderson· 2 shared T. Chandra· 2 shared A. Laird· 1 shared A. Salzano· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

C. Cairns

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

E. D. O'Sullivan, K. J. Mylonas, R. Bell, C. Carbalho, D. P. Baird, C. Cairns, K. M. Gallagher, R. Campbell, M. Docherty, A. Laird, N. Henderson, T. Chandra, K. Kirschner, B. Conway, G. Dihazi, , D. Ferenbach

This study identifies PDIA3 as a key mediator of fibrosis by analyzing senescent epithelia in murine and human models, showing its inhibition reduces fibrosis.

bioRxiv · Mar 21, 2022Cell Biology

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease.

B. R. Conway, E. D. O'Sullivan, C. Cairns, J. O'Sullivan, D. J. Simpson, A. Salzano, K. Connor, P. Ding, D. Humphries, K. Stewart, O. Teenan, N. C. Henderson, C. Benezech, P. Ramachandran, D. Ferenbach, , L. Denby

The paper uses scRNA-seq to study kidney disease progression and regression, identifying new myeloid cell subtypes and their roles in injury and repair.

bioRxiv · May 14, 2020Immunology

Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells

O. Matthews, E. E. Morrison, J. D. Tranter, P. Starkey Lewis, I. Toor, A. Srivastava, R. Sargeant, H. Rollison, K. P. Matchett, G. A. Gray, C. Goldring, K. Park, L. Denby, N. Dhaun, M. A. Bailey, , J. W. Dear

This study shows that hepatocyte-derived microRNA, particularly miR-122, is transferred to kidney tubular cells and regulates CYP2E1 expression, influencing drug toxicity.

bioRxiv · Jan 6, 2020Pharmacology & Toxicology