J. Hughes

Smad4 and TGF-β1 dependent gene expression biomarkers in conditional intestinal adenoma, organoids and colorectal cancer.

The paper identifies Smad4 and TGF-β1 dependent gene expression biomarkers in intestinal adenomas and colorectal cancer using murine models and RNA sequencing.

Ancient genomic linkage couples metabolism with erythroid development

This study identifies Nprl3 as a key regulator of erythroid metabolism, showing its role in coupling metabolic and developmental processes during erythropoiesis.

The OSUMMER lines: a series of ultraviolet-accelerated NRAS-mutant mouse melanoma cell lines syngeneic to C57BL/6

The paper introduces a series of NRAS-mutant melanoma cell lines derived from UV-exposed mice to model human melanoma resistance and therapy responses.

The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2

The paper identifies the recent origin and geographical distribution of bat viruses ancestral to SARS-CoV and SARS-CoV-2, showing they circulated in Asia before spilling over into humans.

Scanning electron microscopy of human islet cilia

This study uses scanning electron microscopy to characterize the ultrastructure of human islet cilia, revealing preserved subdomains and a novel ciliary ring.

An oviduct glycan increases sperm lifespan by diminishing ubiquinone and production of reactive oxygen species

This study identifies an oviduct glycan that extends sperm lifespan by reducing ubiquinone precursor levels and reactive oxygen species production in porcine sperm.

Molecular phenotyping of single pancreatic islet leader beta cells by Flash-Seq

The paper identifies leader beta cells in pancreatic islets using Flash-Seq and finds they have a distinct transcriptome and localization compared to follower cells.

The Ecosystem Integrity Index: a novel measure of terrestrial ecosystem integrity

This paper introduces the Ecosystem Integrity Index (EII), a global measure of terrestrial ecosystem integrity, finding that one fifth of ecosystems and one quarter of ecoregions have lost over half their integrity.

Zoonotic avian influenza viruses evade human BTN3A3 restriction

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

Effective conservation decisions require models designed for purpose: a case study for boreal caribou in Ontario's Ring of Fire

The paper evaluates existing models for predicting mining impacts on boreal caribou in Ontario's Ring of Fire and finds they are ill-suited for regional planning due to lack of specificity and variability across caribou ranges.

Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

This study identifies PDIA3 as a key mediator of fibrosis by analyzing senescent epithelia in murine and human models, showing its inhibition reduces fibrosis.

The Interferon Resistance of Transmitted HIV-1 is a Consequence of Enhanced Replicative Fitness

The paper identifies that transmitted HIV-1's interferon resistance stems from enhanced replicative fitness rather than specific IFN resistance.

Islet primary cilia motility controls insulin secretion

This study shows that primary cilia in pancreatic beta cells move and this movement is essential for glucose-dependent insulin secretion.

Defining the Characteristics of Type I Interferon Stimulated Genes: Insight from Expression Data and Machine Learning

This paper identifies characteristics of type I interferon stimulated genes (ISGs) using expression data and machine learning, finding they are less conserved, have lower GC-content, and differ in network properties compared to non-ISGs.

Exploring the natural origins of SARS-CoV-2 in the light of recombination

This paper traces the origins of SARS-CoV-2 to horseshoe bats in China and Southeast Asia, identifies recombination events in Sarbecoviruses, and highlights the need for more wildlife sampling to understand zoonotic spillover risks.

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease.

The paper uses scRNA-seq to study kidney disease progression and regression, identifying new myeloid cell subtypes and their roles in injury and repair.

TRIM69 inhibits Vesicular Stomatitis Indiana Virus (VSIV)

This study identifies TRIM69 as an interferon-induced gene that potently inhibits VSIV, with specific antiviral activity and evolutionary signatures of positive selection.

Distributed Biomanufacturing of Liquefied Petroleum Gas

This paper demonstrates the production of bio-LPG from waste volatile fatty acids using engineered microbes, offering a sustainable alternative to fossil fuels.

Human Cytomegalovirus Genomes Sequenced Directly from Clinical Material: Variation, Multiple-Strain Infection, Recombination and Mutation

The paper sequences HCMV genomes from clinical samples to study variation, multiple-strain infection, recombination, and mutation, finding that recombinant strains and pseudogenes can persist and cause congenital infections.

Kynurenine 3-monooxygenase (KMO) is a critical regulator of renal ischemia-reperfusion injury

This study shows that KMO inhibition protects against renal ischemia-reperfusion injury in mice by reducing renal damage and inflammation.