N. C. Henderson

Multimodal decoding of human liver regeneration

This study uses single-nuclei RNA sequencing and spatial profiling to create a single-cell atlas of human liver regeneration, identifying a novel migratory hepatocyte subpopulation and demonstrating that wound closure precedes hepatocyte proliferation.

Single cell transcriptomics of Atlantic salmon (Salmo salar L.) liver reveals cellular heterogeneity and immunological responses to challenge by Aeromonas salmonicida

This study uses single-cell transcriptomics to analyze liver cellular heterogeneity and immune responses in Atlantic salmon challenged with Aeromonas salmonicida.

Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation in Human and Murine Liver and Lung Fibrosis

The paper identifies a fibrogenic macrophage subset linked to liver and lung fibrosis across species and shows that targeting specific cytokines reduces fibrosis in models.

Single cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

This study identifies a novel population of PDGFRβ+ mesenchymal cells that undergo mesenchyme-to-epithelial transformation during endometrial repair, contributing to tissue regeneration.

Single cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium

This study uses single-cell RNA sequencing to redefine the mesenchymal cell landscape in mouse endometrium, identifying five subpopulations including pericytes, vascular smooth muscle cells, and three distinct fibroblast subtypes.

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease.

The paper uses scRNA-seq to study kidney disease progression and regression, identifying new myeloid cell subtypes and their roles in injury and repair.

Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells

This study shows that hepatocyte-derived microRNA, particularly miR-122, is transferred to kidney tubular cells and regulates CYP2E1 expression, influencing drug toxicity.

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics

This study uses single-cell transcriptomics to identify novel fibrotic cell types and interactions in human liver cirrhosis, revealing potential therapeutic targets.

The circadian clock protein REVERBα inhibits pulmonary fibrosis development

This study identifies REVERBα as a regulator of pulmonary fibrosis by modulating circadian rhythms and integrin β1 focal adhesion formation in fibroblasts, with potential therapeutic implications.

Neutrophils mediate the capture of peritoneal contaminants by fat-associated lymphoid clusters of the omentum

This study identifies FALC cover cells expressing CXCL1 that recruit neutrophils to neutralize peritoneal contaminants, confirmed in human appendicitis.