Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic Osteoarthritis.
S. K. Bedingfield, F. Yu, D. D. Liu, M. A. Jackson, L. E. Himmel, H. Cho, J. M. Colazo, L. J. Crofford, K. A. Hasty, C. L. Duvall
This paper develops MMP13-targeted nanoparticles for RNA interference to treat post-traumatic osteoarthritis, showing significant reduction in MMP13 expression and cartilage damage in mouse models.
bioRxiv · Jan 30, 2020 · PreprintBioengineering