Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid Nanocarriers
M. A. Jackson, S. S. Patel, F. Yu, M. A. Cottam, E. B. Glass, B. R. Dollinger, E. N. Hoogenboezem, P. Patil, D. D. Liu, I. B. Kelly, S. K. Bedingfield, A. R. King, R. E. Miles, A. M. Hasty, T. D. Giorgio, C. L. Duvall
This paper identifies Kupffer cell release of platelet activating factor (PAF) as a key driver of nanocarrier toxicity and shows that PAFR inhibition prevents dose-limiting toxicities in mice.
bioRxiv · Feb 11, 2020Bioengineering