Author

K. A. Hasty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Animal Behavior & Cognition· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

C. L. Duvall· 3 shared H. Cho· 3 shared J. M. Colazo· 3 shared D. D. Brand· 2 shared F. Yu· 2 shared A. G. Sorets· 1 shared B. L. Walton· 1 shared C. A. Hamann· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBioengineering

C. L. Duvall

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine

B. L. Walton, R. Shattuck-Brandt, C. A. Hamann, V. W. Tung, J. M. Colazo, D. D. Brand, K. A. Hasty, C. L. Duvall, J. M. Brunger

This paper develops a synthetic receptor system that enables mesenchymal stromal cells to target and respond specifically to damaged cartilage in osteoarthritis.

bioRxiv · Jan 31, 2024Bioengineering

Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

J. M. Colazo, E. N. Hoogenboezem, M. C. Keech, N. Francini, V. Shah, F. Yu, J. H. Lo, A. G. Sorets, J. T. McCune, H. Cho, C. R. DeJulius, D. L. Michell, T. Maerz, K. C. Vickers, K. N. Gibson-Corley, , C. L. Duvall

This paper develops an MMP13-targeting siRNA conjugate that preferentially accumulates in arthritic joints, reducing disease markers and outperforming current treatments.

bioRxiv · May 31, 2023 · PreprintBioengineering

Robust Characterization of Non-Invasive Post-Traumatic Osteoarthritis Mouse Model

F.-U.-R. Bhatti, Y.-H. Jeong, D.-G. Kim, D. D. Brand, K. A. Hasty, H. Cho

This study characterizes a non-invasive mouse model of post-traumatic osteoarthritis by analyzing biochemical, biomechanical, and behavioral changes following mechanical knee loading.

bioRxiv · May 28, 2021 · PreprintAnimal Behavior & Cognition

Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic Osteoarthritis.

S. K. Bedingfield, F. Yu, D. D. Liu, M. A. Jackson, L. E. Himmel, H. Cho, J. M. Colazo, L. J. Crofford, K. A. Hasty, C. L. Duvall

This paper develops MMP13-targeted nanoparticles for RNA interference to treat post-traumatic osteoarthritis, showing significant reduction in MMP13 expression and cartilage damage in mouse models.

bioRxiv · Jan 30, 2020 · PreprintBioengineering