Author

S. K. Bedingfield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

C. L. Duvall· 3 shared D. D. Liu· 2 shared F. Yu· 2 shared J. M. Colazo· 2 shared M. A. Jackson· 2 shared A. J. Kwiatkowski· 1 shared A. M. Hasty· 1 shared A. R. King· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBioengineering

C. L. Duvall

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3 papers

Recent·Most cited

Galectin-anchored indoleamine 2,3-dioxygenase suppresses local inflammation

E. Bracho-Sanchez, F. Rocha, S. K. Bedingfield, B. D. Partain, M. A. Brusko, J. M. Colazo, M. M. Fettis, S. A. Farhadi, E. Y. Helm, K. Koenders, A. J. Kwiatkowski, S. L. Macias, A. Restuccia, A. Wanchoo, D. Avram, , B. G. Keselowsky

This paper develops a fusion protein IDO-Gal3 that anchors immunosuppressive enzymes to tissues, effectively suppressing local inflammation in multiple disease models.

bioRxiv · May 7, 2021 · PreprintBioengineering

Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid Nanocarriers

M. A. Jackson, S. S. Patel, F. Yu, M. A. Cottam, E. B. Glass, B. R. Dollinger, E. N. Hoogenboezem, P. Patil, D. D. Liu, I. B. Kelly, S. K. Bedingfield, A. R. King, R. E. Miles, A. M. Hasty, T. D. Giorgio, C. L. Duvall

This paper identifies Kupffer cell release of platelet activating factor (PAF) as a key driver of nanocarrier toxicity and shows that PAFR inhibition prevents dose-limiting toxicities in mice.

bioRxiv · Feb 11, 2020Bioengineering

Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic Osteoarthritis.

S. K. Bedingfield, F. Yu, D. D. Liu, M. A. Jackson, L. E. Himmel, H. Cho, J. M. Colazo, L. J. Crofford, K. A. Hasty, C. L. Duvall

This paper develops MMP13-targeted nanoparticles for RNA interference to treat post-traumatic osteoarthritis, showing significant reduction in MMP13 expression and cartilage damage in mouse models.

bioRxiv · Jan 30, 2020 · PreprintBioengineering