Author

L. E. Kuek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1

Frequent Co-Authors

D. B. McMahon· 3 shared J. N. Palmer· 3 shared N. D. Adappa· 3 shared R. J. Lee· 3 shared J. F. Jolivert· 2 shared M. E. Johnson· 1 shared P. O. Johnson· 1 shared R. L. J. Horn· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersPhysiology

D. B. McMahon

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3 papers

Recent·Most cited

Savory Signaling: T1R umami receptor modulates endoplasmic reticulum calcium store content and release dynamics in airway epithelial cells

D. B. McMahon, J. F. Jolivert, L. E. Kuek, N. D. Adappa, J. N. Palmer, R. J. Lee

The paper investigates how T1R receptors modulate ER calcium dynamics in airway epithelial cells and shows amino acids reduce ER Ca2+ content and downstream apoptosis signaling.

bioRxiv · Dec 7, 2022Physiology

Cilia stimulatory and antibacterial activities of bitter receptor agonist diphenhydramine: insights into potential complimentary strategies for CF nasal infections

L. E. Kuek, D. B. McMahon, R. Z. Ma, Z. A. Miller, J. F. Jolivert, N. D. Adappa, J. N. Palmer, R. J. Lee

This study shows diphenhydramine, a T2R14 agonist, increases nitric oxide and cilia beating while reducing Pseudomonas aeruginosa growth and biofilm in nasal epithelial cells.

bioRxiv · Jan 31, 2022Physiology

The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells

D. B. McMahon, L. E. Kuek, M. E. Johnson, P. O. Johnson, R. L. J. Horn, R. M. Carey, N. D. Adappa, J. N. Palmer, R. J. Lee

This study shows T2R agonists induce apoptosis in non-ciliated airway cells through nuclear calcium and mitochondrial pathways, potentially as a defense against infection or a risk in disease.

bioRxiv · May 16, 2021Physiology