The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells
D. B. McMahon, L. E. Kuek, M. E. Johnson, P. O. Johnson, R. L. J. Horn, R. M. Carey, N. D. Adappa, J. N. Palmer, R. J. Lee
This study shows T2R agonists induce apoptosis in non-ciliated airway cells through nuclear calcium and mitochondrial pathways, potentially as a defense against infection or a risk in disease.
bioRxiv · May 16, 2021Physiology