N. D. Adappa

Savory Signaling: T1R umami receptor modulates endoplasmic reticulum calcium store content and release dynamics in airway epithelial cells

The paper investigates how T1R receptors modulate ER calcium dynamics in airway epithelial cells and shows amino acids reduce ER Ca2+ content and downstream apoptosis signaling.

Akt activator SC79 stimulates antibacterial nitric oxide production from human nasal epithelial cells and increases macrophage phagocytosis in vitro

This study shows SC79, an Akt activator, increases NO production in nasal epithelial cells and enhances macrophage phagocytosis without toxicity.

Taste receptor T1R3 in nasal cilia detects Staphylococcus aureus D-amino acids to increase apical glucose uptake and enhance innate immunity

The paper shows that T1R3 in nasal cilia detects D-amino acids from Staphylococcus aureus to reduce airway surface liquid glucose and enhance innate immunity.

Bitter taste receptor-stimulated nitric oxide innate immune responses are reduced by loss of CFTR function in nasal epithelial cells and macrophages

This study shows that loss of CFTR function reduces T2R-stimulated NO production in nasal epithelial cells and macrophages, impairing immune responses to gram-negative bacteria.

Cilia stimulatory and antibacterial activities of bitter receptor agonist diphenhydramine: insights into potential complimentary strategies for CF nasal infections

This study shows diphenhydramine, a T2R14 agonist, increases nitric oxide and cilia beating while reducing Pseudomonas aeruginosa growth and biofilm in nasal epithelial cells.

HSP90 modulates T2R bitter taste receptor nitric oxide production and innate immune responses in human airway epithelial cells and macrophages

This study shows HSP90 regulates T2R-dependent NO production and innate immune responses in airway cells, enhancing antibacterial defenses.

The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells

This study shows T2R agonists induce apoptosis in non-ciliated airway cells through nuclear calcium and mitochondrial pathways, potentially as a defense against infection or a risk in disease.

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

This study investigates how SARS-CoV-2 interacts with host antiviral pathways in respiratory and cardiac cells, finding it activates OAS-RNase L and PKR but not IFN, contrasting with MERS-CoV.

Altered polarization of PAR-2 signaling during airway epithelial remodeling

The paper examines how PAR-2 signaling polarization changes in airway epithelial cells during remodeling, finding increased apical responses in squamous metaplasia and loss of cilia.

Inverse regulation of secretion and inflammation in human airway gland serous cells by neuropeptides upregulated in allergy and asthma

This study investigates how neuropeptides VIP and NPY regulate secretion and inflammation in human airway gland serous cells, showing opposing effects on fluid secretion, antimicrobial activity, and cytokine release.