Author

L. E. Salay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. F. Eichman· 2 shared E. A. Mullins· 2 shared W. J. Chazin· 2 shared B. A. Webb· 1 shared C. L. Durie· 1 shared E. M. Lynch· 1 shared H. Hansen· 1 shared J. E. Jackman· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

B. F. Eichman

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3 papers

Recent·Most cited

A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase

E. A. Mullins, L. E. Salay, C. L. Durie, N. P. Bradley, J. E. Jackman, M. D. Ohi, W. J. Chazin, B. F. Eichman

This study presents cryo-EM structures of DNA polymerase α-primase complexes to elucidate the mechanism of primer synthesis and its regulation.

Nature Structural & Molecular Biology · Mar 15, 2024Peer-reviewedBiochemistry

Structural basis for allosteric regulation of human phosphofructokinase-1

E. M. Lynch, H. Hansen, L. E. Salay, M. Cooper, S. Timr, J. M. Kollman, B. A. Webb

This study determines the cryoEM structures of human PFK1 in R- and T-states, revealing eukaryotic allosteric regulation mechanisms and the role of the C-terminus in autoinhibition.

bioRxiv · Mar 15, 2024Biochemistry

Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase

J. J. Cordoba, E. A. Mullins, L. E. Salay, B. F. Eichman, W. J. Chazin

This study investigates RNA primer synthesis and handoff in human DNA polymerase α-primase, showing that flexibility and distributive synthesis are key to primer generation and transfer.

bioRxiv · Aug 1, 2023Biochemistry