B. F. Eichman

A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase

This study presents cryo-EM structures of DNA polymerase α-primase complexes to elucidate the mechanism of primer synthesis and its regulation.

Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase

This study investigates RNA primer synthesis and handoff in human DNA polymerase α-primase, showing that flexibility and distributive synthesis are key to primer generation and transfer.

Abasic site ring opening and DNA-protein crosslink reversal by the SRAP protein YedK

This study identifies the SRAP domain's role in converting AP sites to aldehyde forms and reversing DNA-protein crosslinks using the bacterial protein YedK.

RTEL1 and MCM10 overcome topological stress during vertebrate replication termination

The paper identifies RTEL1 and MCM10 as proteins that help replication forks overcome topological stress during DNA synthesis termination in Xenopus egg extracts.

Extensive loss of cell cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts

This study identifies two lineages in Hanseniaspora yeasts, showing the FEL lineage lost more cell cycle and DNA repair genes than the SEL lineage, likely due to accelerated evolution and increased mutational load.