M. D. Ohi

A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase

This study presents cryo-EM structures of DNA polymerase α-primase complexes to elucidate the mechanism of primer synthesis and its regulation.

Evolutionarily diverse caveolins share a common structural framework built around amphipathic discs

The paper predicts structures for 73 caveolins across animal diversity and identifies conserved structural elements and amphipathic disc assembly, revealing an ancient structural framework predating Metazoa.

Structural characterization of a breast cancer-associated mutation in caveolin-1

This study examines how a breast cancer-associated mutation in CAV1, P132L, affects its structure and oligomerization, revealing its impact on caveolae formation.

Molecular architecture of the human caveolin-1 complex

The paper uses cryo-electron microscopy to reveal the structure of the human caveolin-1 complex, showing it forms a disc with a flat membrane-binding surface.

Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS

The paper uses cryo-EM to determine the structure of the Legionella pneumophila Dot/Icm T4SS, identifying new proteins and symmetry elements that contribute to its function.

Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

The paper uses cryo-EM to reveal the structure of H. pylori T4SS core complex components, showing species-specific arrangements and ratios.

Structural analysis of the Legionella pneumophila Dot/Icm Type IV Secretion System Core Complex

The paper reports the structural analysis of the Legionella pneumophila Dot/Icm T4SS core complex using cryo-EM, revealing its stoichiometry and protein interactions.

Structure and assembly of CAV1 8S complexes revealed by single particle electron microscopy

This study uses single particle electron microscopy to reveal the structure of human CAV1 8S complexes, showing they are toroidal with distinct rings and stalks, and provides insights into their assembly.

Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters

This study shows HSET forms MT asters using soluble tubulin, not pre-formed MTs, and proposes a model where tubulin availability governs aster versus bundle formation.