Author

L. E. Vostal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

T. M. Kapoor· 2 shared B. T. Chait· 1 shared D. J. Huggins· 1 shared E. V. Vinogradova· 1 shared H. Soileau· 1 shared J. R. Ramsey· 1 shared L. Urnavicius· 1 shared M. Grasso· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

T. M. Kapoor

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Author profile →

2 papers

Recent·Most cited

Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicry

N. H. Jones, Q. Liu, L. Urnavicius, N. E. Dahan, L. E. Vostal, T. M. Kapoor

This paper identifies VA1, a small molecule that activates VCP/p97, and reveals its allosteric mechanism through cryo-EM structures and mutagenesis studies.

bioRxiv · Oct 2, 2023 · PreprintBiochemistry

Using a function-first "scout fragment"-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes

J. R. Ramsey, P. M. M. Shelton, T. K. Heiss, P. D. B. Olinares, L. E. Vostal, H. Soileau, M. Grasso, S. Warrington, S. Adaniya, M. Miller, S. Sun, D. J. Huggins, R. W. Myers, B. T. Chait, E. V. Vinogradova, T. M. Kapoor

The paper develops covalent inhibitors for conformationally dynamic helicases using electrophilic scout fragments and a function-first approach, targeting SARS-CoV-2 nsp13 and human helicases BLM and WRN.

bioRxiv · Sep 25, 2023Biochemistry