D. J. Huggins

Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior

The paper identifies three new small molecule agonists for NPYLR7 that suppress mosquito blood feeding at lower doses than previous compounds.

Using a function-first "scout fragment"-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes

The paper develops covalent inhibitors for conformationally dynamic helicases using electrophilic scout fragments and a function-first approach, targeting SARS-CoV-2 nsp13 and human helicases BLM and WRN.

Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs

This paper describes the development of a more potent Lats kinase inhibitor, TDI-011536, which promotes cell proliferation and regeneration in mammalian tissues.

A chemical strategy toward novel brain-penetrant EZH2 inhibitors

This paper identifies a chemical strategy to develop brain-penetrant EZH2 inhibitors and reports two novel compounds with improved properties.

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.