Uncovering the modified immunopeptidome reveals insights into principles of PTM-driven antigenicity
A. Kacen, A. Javitt, M. P. Kramer, D. Morgenstern, T. Tsaban, A. Solomon, G. C. Teo, F. da Veiga Leprevost, E. Barnea, F. Yu, A. Admon, L. Eisenbach, G. Cafri, O. Schueler-Furman, Y. Levin, , Y. Merbl
The paper identifies thousands of novel cancer-specific antigens by analyzing PTMs in immunopeptidomics data from multiple sources and reveals their impact on HLA binding and TCR recognition.
bioRxiv · Apr 10, 2021 · PreprintCancer Biology