Structural study of UFL1-UFC1 interaction uncovers the importance of UFL1 N-terminal helix for ufmylation
S. Banerjee, J. K. Varga, M. Kumar, G. Zoltsman, M. N. Isupov, R. Rosenzweig, O. Schueler-Furman, R. Wiener
This study reveals the role of UFL1's N-terminal helix in binding UFC1 and ufmylation, uncovering a helix-mediated regulatory mechanism in the E1-E2-E3 cascade.
bioRxiv · Sep 15, 2022 · PreprintBiochemistry