Author

F. da Veiga Leprevost

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Immunology· 1

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. I. Nesvizhskii· 5 shared V. Basrur· 3 shared D. Ginsburg· 2 shared F. Yu· 2 shared P. S. Abbineni· 2 shared V. T. Tang· 2 shared A. Admon· 1 shared A. Javitt· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersBiophysics

A. I. Nesvizhskii

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Identification of LMAN1 and SURF4 dependent secretory cargoes

V. T. Tang, P. S. Abbineni, F. da Veiga Leprevost, V. Basrur, B. T. Emmer, A. Nesvizhskii, D. Ginsburg

The paper identifies secretory cargoes dependent on LMAN1 and SURF4 using CRISPR knockout and mass spectrometry in HuH7 cells, revealing distinct cargo repertoires and complex recognition mechanisms.

bioRxiv · Apr 6, 2023Cell Biology

Autoinhibited kinesin-1 adopts a hierarchical folding pattern

Z. Tan, Y. Yue, F. da Veiga Leprevost, S. E. Haynes, V. Basrur, A. I. Nesvizhskii, K. J. Verhey, M. A. Cianfrocco

This study determines the structure of autoinhibited kinesin-1 using XL-MS, EM, and AlphaFold, showing how light chains stabilize the inhibited state and how activation requires disrupting multiple domain interactions.

bioRxiv · Jan 26, 2023Biophysics

HLA-Glyco: A large-scale interrogation of the glycosylated immunopeptidome

G. Bedran, D. A. Polasky, H. Yi, F. Yu, F. da Veiga Leprevost, J. A. Alfaro, M. Cieslik, A. I. Nesvizhskii

The paper develops a computational workflow for glyco-immunopeptidomics, identifies glycosylated MHC class II peptides, and provides a resource with over 3,400 HLA class II N-glycopeptides.

bioRxiv · Dec 5, 2022 · PreprintImmunology

Identification of secreted proteins by comparison of protein abundance in conditioned media and cell lysates.

P. S. Abbineni, V. T. Tang, F. da Veiga Leprevost, V. Basrur, J. Xiang, A. I. Nesvizhskii, D. Ginsburg

The paper identifies secreted proteins by comparing their abundance in conditioned media and cell lysates, finding proteins enriched in media as potential secreted candidates.

bioRxiv · Jun 16, 2022Biochemistry

GRASP55 regulates mutant huntingtin unconventional secretion and aggregation

E. Ahat, S. Bui, J. Zhang, F. da Veiga Leprevost, L. M. Sharkey, W. Reid, A. I. Nesvizhskii, H. L. Paulson, Y. Wang

This study shows GRASP55 promotes mutant huntingtin secretion via autophagy and stress conditions, reducing aggregation and toxicity.

bioRxiv · Oct 5, 2021Cell Biology

Uncovering the modified immunopeptidome reveals insights into principles of PTM-driven antigenicity

A. Kacen, A. Javitt, M. P. Kramer, D. Morgenstern, T. Tsaban, A. Solomon, G. C. Teo, F. da Veiga Leprevost, E. Barnea, F. Yu, A. Admon, L. Eisenbach, G. Cafri, O. Schueler-Furman, Y. Levin, , Y. Merbl

The paper identifies thousands of novel cancer-specific antigens by analyzing PTMs in immunopeptidomics data from multiple sources and reveals their impact on HLA binding and TCR recognition.

bioRxiv · Apr 10, 2021 · PreprintCancer Biology