Author

Y. Merbl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Javitt· 2 shared A. Kacen· 2 shared M. P. Kramer· 2 shared Y. Levin· 2 shared A. A. Kolodziejczyk· 1 shared A. Admon· 1 shared A. Bajaj· 1 shared A. Eisenberg-Lerner· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

A. Javitt

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rab7 dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

P. Gaur, Y. Rajendran, B. Srivastava, M. Markandey, V. Fishbain-Yoskovitz, G. Mohapatra, A. Suhail, S. Chaudhary, S. Tyagi, S. C. Yadav, A. K. Pandey, Y. Merbl, A. Bajaj, V. Ahuja, C. Srikanth

This study shows Rab7 regulates CLCA1 in goblet cells, affecting mucus composition and gut microbiota, leading to increased susceptibility to colitis.

bioRxiv · Feb 13, 2023Cell Biology

The proteasome regulator PSME4 drives immune evasion and abrogates anti-tumor immunity in NSCLC

A. Javitt, M. D. Shmueli, M. P. Kramer, A. A. Kolodziejczyk, I. J. Cohen, I. Kamer, K. Litchfield, E. Bab-Dinitz, O. Zadok, V. Neiens, A. Ulman, L. Radomir, H. Wolf-Levy, A. Eisenberg-Lerner, A. Kacen, , Y. Merbl

This paper identifies PSME4 as a proteasome regulator that suppresses anti-tumor immunity in NSCLC by inhibiting immunoproteasome activity and antigen presentation.

bioRxiv · Oct 24, 2021 · PreprintCancer Biology

Uncovering the modified immunopeptidome reveals insights into principles of PTM-driven antigenicity

A. Kacen, A. Javitt, M. P. Kramer, D. Morgenstern, T. Tsaban, A. Solomon, G. C. Teo, F. da Veiga Leprevost, E. Barnea, F. Yu, A. Admon, L. Eisenbach, G. Cafri, O. Schueler-Furman, Y. Levin, , Y. Merbl

The paper identifies thousands of novel cancer-specific antigens by analyzing PTMs in immunopeptidomics data from multiple sources and reveals their impact on HLA binding and TCR recognition.

bioRxiv · Apr 10, 2021 · PreprintCancer Biology