Author

A. Kacen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Javitt· 2 shared A. Millman· 2 shared G. Amitai· 2 shared M. P. Kramer· 2 shared N. Tal· 2 shared R. Sorek· 2 shared S. Doron· 2 shared S. Melamed· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

A. Javitt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cryo-EM structure of the RADAR supramolecular anti-phage defense complex

B. Duncan-Lowey, N. Tal, A. G. Johnson, S. Rawson, M. L. Mayer, S. Doron, A. Millman, S. Melamed, T. Fedorenko, A. Kacen, G. Amitai, R. Sorek, P. J. Kranzusch

The paper determines the cryo-EM structure of the RADAR complex, showing RdrB targets mononucleotides and catalyzes ATP-to-ITP conversion to limit phage replication.

Cell · Mar 1, 2023Peer-reviewedBiochemistry

An expanding arsenal of immune systems that protect bacteria from phages

A. Millman, S. Melamed, A. Leavitt, S. Doron, A. Bernheim, J. Hör, A. Lopatina, G. Ofir, D. Hochhauser, A. Stokar-Avihail, N. Tal, S. Sharir, M. Voichek, Z. Erez, J. L. M. Ferrer, , R. Sorek

This study identifies 21 new bacterial defense systems against phages through genomic analysis and experiments, revealing novel protein domains and toxin-antitoxin mechanisms involved in anti-phage immunity.

bioRxiv · May 11, 2022Microbiology

The proteasome regulator PSME4 drives immune evasion and abrogates anti-tumor immunity in NSCLC

A. Javitt, M. D. Shmueli, M. P. Kramer, A. A. Kolodziejczyk, I. J. Cohen, I. Kamer, K. Litchfield, E. Bab-Dinitz, O. Zadok, V. Neiens, A. Ulman, L. Radomir, H. Wolf-Levy, A. Eisenberg-Lerner, A. Kacen, , Y. Merbl

This paper identifies PSME4 as a proteasome regulator that suppresses anti-tumor immunity in NSCLC by inhibiting immunoproteasome activity and antigen presentation.

bioRxiv · Oct 24, 2021 · PreprintCancer Biology

Uncovering the modified immunopeptidome reveals insights into principles of PTM-driven antigenicity

A. Kacen, A. Javitt, M. P. Kramer, D. Morgenstern, T. Tsaban, A. Solomon, G. C. Teo, F. da Veiga Leprevost, E. Barnea, F. Yu, A. Admon, L. Eisenbach, G. Cafri, O. Schueler-Furman, Y. Levin, , Y. Merbl

The paper identifies thousands of novel cancer-specific antigens by analyzing PTMs in immunopeptidomics data from multiple sources and reveals their impact on HLA binding and TCR recognition.

bioRxiv · Apr 10, 2021 · PreprintCancer Biology