DYT1 dystonia patient-derived fibroblasts have increased deformability and susceptibility to damage by mechanical forces.
N. K. Gill, C. Ly, P. H. Kim, C. A. Saunders, L. G. Fong, S. G. Young, G. G. Luxton, A. C. Rowat
This study examines the mechanotype of fibroblasts from DYT1 dystonia patients and mice lacking torsinA, finding increased deformability and susceptibility to mechanical damage.
bioRxiv · Nov 28, 2018Biophysics