Author

A. C. Rowat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:mouse· 3 Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2

Frequent Co-Authors

C. Ly· 2 shared J. Soto· 2 shared S. Li· 2 shared T. Hoffman· 2 shared T.-H. Kim· 2 shared Y. Song· 2 shared A. Abdou· 1 shared A. Christodoulides· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

C. Ly

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

Y. Wu, Y. Song, J. Soto, T. Hoffman, X. Lin, A. Zhang, S. Chen, R. N. Massad, X. Han, D. Qi, K.-W. Yeh, Z. Fang, J. Eoh, L. Gu, A. C. Rowat, , S. Li

This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.

bioRxiv · Apr 14, 2024Cell Biology

Histone H1.0 Couples Cellular Mechanical Behaviors to Chromatin Structure

S. Hu, D. J. Chapski, N. Gehred, T. H. Kimball, T. Gromova, A. Flores, A. C. Rowat, J. J. Chen, R. R. S. Packard, E. Olszewski, J. Davis, C. D. Rau, T. A. McKinsey, M. Rosa-Garrido, T. M. Vondriska

This study shows that histone H1.0 regulates cellular mechanical behaviors by controlling chromatin structure and gene expression in response to extracellular stress.

bioRxiv · Nov 29, 2022Cell Biology

Transient nuclear deformation primes epigenetic state and promotes cell reprogramming

Y. Song, J. Soto, B. Chen, W. Zhao, T. Hoffman, N. Zhu, Q. Peng, C. Ly, P. K. Wong, Y. Wang, A. C. Rowat, S. K. Kurdistani, S. Li

This study shows that transient nuclear deformation enhances cell reprogramming by altering epigenetic states, specifically reducing DNA methylation and H3K9 methylation.

bioRxiv · May 19, 2021Biophysics

β-adrenergic signaling modulates cancer cell mechanotype through a RhoA-ROCK-myosin II axis

T.-H. Kim, E. Vazquez-Hidalgo, A. Abdou, X. H. M. Tan, A. Christodoulides, C. M. Farris, P. Y. Chiou, E. K. Sloan, P. Katira, A. C. Rowat

This study identifies a β-adrenergic signaling pathway that modulates cancer cell mechanotype via RhoA-ROCK-myosin II axis, increasing stiffness and invasion.

bioRxiv · Sep 23, 2019 · PreprintCancer Biology

Cancer cells resist mechanical destruction in the circulation via RhoA-myosin II axis

D. L. Moose, B. L. Krog, L. Zhao, T.-H. Kim, S. Williams-Perez, G. Burke, L. Rhodes, M. Vanneste, P. Breheny, M. Milhem, C. S. Stipp, A. C. Rowat, M. D. Henry

This study identifies the RhoA-myosin II axis as a mechanism enabling cancer cells to resist mechanical destruction by hemodynamic forces in circulation.

bioRxiv · Apr 6, 2019Cancer Biology

DYT1 dystonia patient-derived fibroblasts have increased deformability and susceptibility to damage by mechanical forces.

N. K. Gill, C. Ly, P. H. Kim, C. A. Saunders, L. G. Fong, S. G. Young, G. G. Luxton, A. C. Rowat

This study examines the mechanotype of fibroblasts from DYT1 dystonia patients and mice lacking torsinA, finding increased deformability and susceptibility to mechanical damage.

bioRxiv · Nov 28, 2018Biophysics