Author

S. G. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

A. C. Rowat· 1 shared A. C. W. Pike· 1 shared A. Chu· 1 shared A. Ferrari· 1 shared A. H. Bedard· 1 shared A. Nguyen· 1 shared A. Quigley· 1 shared B. Romartinez- Alonso· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperBiophysics

A. C. Rowat

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Author profile →

3 papers

Recent·Most cited

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

A. Ferrari, E. Whang, X. Xiao, J. P. Kennelly, B. Romartinez- Alonso, J. J. Mack, T. Weston, K. Chen, Y. Kim, M. Tol, L. Bideyan, A. Nguyen, Y. Gao, L. Cui, A. H. Bedard, , P. Tontonoz

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

bioRxiv · Jul 7, 2023 · PreprintPhysiology

A new paradigm for Prelamin A proteolytic processing by ZMPSTE24: the upstream SY^LL cleavage occurs first and there is no CaaX processing by ZMPSTE24

L. Nie, E. Spear, T. D. Babatz, A. Quigley, Y. Y. Dong, A. Chu, B. Rotty, R. Chalk, S. M. M. Mukhopadhyay, N. A. Burgess-Brown, A. C. W. Pike, S. G. Young, S. Michaelis, E. P. Carpenter

This study challenges the established order of prelamin A processing by ZMPSTE24, showing that SY^LL cleavage occurs first and independently of C-terminal modifications.

bioRxiv · May 13, 2020 · PreprintBiochemistry

DYT1 dystonia patient-derived fibroblasts have increased deformability and susceptibility to damage by mechanical forces.

N. K. Gill, C. Ly, P. H. Kim, C. A. Saunders, L. G. Fong, S. G. Young, G. G. Luxton, A. C. Rowat

This study examines the mechanotype of fibroblasts from DYT1 dystonia patients and mice lacking torsinA, finding increased deformability and susceptibility to mechanical damage.

bioRxiv · Nov 28, 2018Biophysics