Author

L. G. Spector

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

J. F. Modiano· 2 shared L. J. Mills· 2 shared S. Subramanian· 2 shared A. Deshpande· 1 shared A. J. Donnelly· 1 shared A. Khammanivong· 1 shared A. L. Sarver· 1 shared A. Montoya· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

J. F. Modiano

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2 papers

Recent·Most cited

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

K. Makielski, A. J. Donnelly, A. Khammanivong, M. C. Scott, A. R. Ortiz, D. C. Galvan, H. Tomiyasu, C. Amaya, K. Ward, A. Montoya, J. R. Garbe, L. J. Mills, G. R. Cutter, J. M. Fenger, W. C. Kisseberth, , J. F. Modiano

The paper develops a gene signature using exosomal RNA from canine osteosarcoma xenografts and machine learning to detect residual disease in dogs, showing improved remission outcomes in validation samples.

bioRxiv · Feb 11, 2021Cancer Biology

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma

L. J. Mills, M. Scott, P. Shah, A. R. Cunanan, A. Deshpande, B. Auch, B. Curtin, K. B. Beckman, L. G. Spector, A. L. Sarver, S. Subramanian, T. Richmond, J. F. Modiano

This study identifies DNA methylation patterns in human and canine osteosarcoma samples that correlate with conserved transcriptional programs and tumor states, not cell composition.

bioRxiv · Apr 29, 2020Cancer Biology