Cell response to extracellular matrix energy dissipation outweighs rigidity sensing
C. Huerta-Lopez, A. Clemente-Manteca, D. Velazquez-Carreras, F. M. Espinosa, J. G. Sanchez, P. Saez, A. Martinez-del-Pozo, M. Garcia-Garcia, S. Martin-Colomo, A. Rodriguez-Blanco, R. Esteban-Gonzalez, F. M. Martin-Zamora, L. Gutierrez-Rus, R. Garcia, P. Roca-Cusachs, , J. Alegre-Cebollada
The paper shows that substrate energy dissipation suppresses YAP mechanosensing more than stiffness cues in cell mechanotransduction.
bioRxiv · Nov 16, 2022Bioengineering