J. Alegre-Cebollada

Imaging of existing and newly translated proteins elucidates mechanisms of sarcomere turnover

The paper uses imaging to show that sarcomere proteins are replaced by newly translated ones, disproving the existing protein pool model and revealing a unidirectional replacement mechanism.

Amino acid substitutions hydrophilizing the core of titin domains cause dilated cardiomyopathy

The paper identifies amino acid substitutions in titin domains that increase hydrophilicity and cause dilated cardiomyopathy by destabilizing the protein structure.

Cell response to extracellular matrix energy dissipation outweighs rigidity sensing

The paper shows that substrate energy dissipation suppresses YAP mechanosensing more than stiffness cues in cell mechanotransduction.

Nanomechanical phenotypes in cMyBP-C mutants that cause hypertrophic cardiomyopathy

This study investigates nanomechanical changes in cMyBP-C mutants linked to hypertrophic cardiomyopathy, finding that pathogenic mutations alter mechanical properties compared to non-pathogenic variants.

A HaloTag-TEV genetic cassette for mechanical phenotyping of proteins from tissues

The paper introduces a HaloTag-TEV genetic cassette to study protein mechanics in native tissues, showing titin's role in muscle contraction under mechanical forces.

Concurrent Atomic Force Spectroscopy

This paper introduces concurrent AFM force measurements to improve the accuracy and throughput of mechanical property quantification in single-molecule studies.