B. W. Day

Spatial Transcriptomic Sequencing of a DIPG-infiltrated Brainstem reveals Key Invasion Markers and Novel Ligand-Receptor Pairs contributing to Tumour to TME Crosstalk

This study uses spatial transcriptomics to analyze a DIPG-infiltrated brainstem, identifying invasion markers and ligand-receptor pairs involved in tumour-TME crosstalk.

ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines

This study shows that ATR inhibition with gartisertib enhances cell death and synergizes with TMZ and RT in glioblastoma cell lines, particularly in TMZ-resistant cells.

Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells

The paper investigates Calcitriol's effect on glioma stem-like cells, finding that some cell lines are sensitive while others are resistant, linked to Vitamin D3 receptor polymorphisms and proteomic changes.

Targeting OLIG2 increases therapeutic responses in SHH medulloblastoma mouse models and patient-derived medulloblastoma organoids

This study shows that targeting OLIG2 with CT-179 reduces recurrence in SHH medulloblastoma models and improves survival when combined with radiotherapy.

A short ERK5 isoform modulates nucleocytoplasmic shuttling of active ERK5 and associates with poor survival in breast cancer

This paper identifies a short ERK5 isoform that promotes extranuclear localization of active ERK5, driving EMT and poor survival in breast cancer.

Immunophenotyping of HER4/YAP axis in breast cancer brain metastasis

This study investigates the HER4/YAP axis in breast cancer brain metastasis using patient samples, finding HER4 phosphorylation is specific to BrM but YAP phosphorylation is not a major consequence of HER4 activation.

Direct evidence for transport of RNA from the mouse brain to the germline and offspring

This study demonstrates that somatic RNA from the mouse brain can be transported to the germline and passed to offspring.

Transcription factors NFIA and NFIB induce cellular differentiation high-grade astrocytoma

This study shows that NFIA and NFIB promote differentiation in high-grade astrocytoma by reducing their expression in glioblastomas and inducing differentiation in xenografts.