Q. Nguyen

Mapping fibrotic microenvironments: single-cell and spatial profiling of Schistosoma mansoni-induced tissue fibrosis

This study uses single-cell spatial transcriptomics to map fibrotic microenvironments in Schistosoma mansoni-infected mice, revealing organ-specific fibrosis architecture and shared signaling pairs for potential therapeutic targets.

Named Entity Recognition of Pharmacokinetic parameters in the scientific literature

This paper introduces a novel corpus and language models for Named Entity Recognition of pharmacokinetic parameters in scientific literature, achieving high accuracy with BioBERT.

Pharmacological and behavioral effects of tryptamines present in psilocybin-containing mushrooms

This study compares the pharmacological and behavioral effects of tryptamines in psilocybin-containing mushrooms, finding that norbaeocystin may have therapeutic potential similar to psilocybin without causing hallucinations.

A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer

The paper identifies a 26-gene expression signature in high-risk gastric intestinal metaplasia (GIM) that localizes to intestinal stem-like cells and is associated with increased gastric cancer risk.

Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia

The paper identifies mutation patterns linked to drug sensitivity in AML using integrated computational and experimental analysis.

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

Benchmarking robust spatial transcriptomics approaches to capture the molecular landscape and pathological architecture of archived cancer tissues

This study benchmarks spatial transcriptomics methods on archived FFPE cancer tissues, revealing molecular landscapes and pathological features, including non-coding RNA expression.

Deep spatial-omics to aid personalization of precision medicine in metastatic recurrent Head & Neck Cancers

This study uses spatial-omics to identify tumor metabolic states and immune cell profiles in OPSCC, leading to insights on ICI failure and potential drug targets.

Dehydration alters transcript levels in the mosquito midgut, likely facilitating rapid rehydration

This study shows dehydration alters midgut gene expression in Aedes aegypti, enabling faster rehydration after bloodfeeding and potentially affecting pathogen transmission.

Cellular Heterogeneity of Pluripotent Stem Cell Derived Cardiomyocyte Grafts is Mechanistically Linked to Treatable Arrhythmias

This study identifies arrhythmogenic subpopulations in pluripotent stem cell-derived cardiomyocytes and shows that combination therapy and catheter ablation can reduce engraftment arrhythmias.

Chorography and conformational dynamism of the Soluble Human Fibrinogen in solution

This study presents a conformationally dynamic model of soluble human fibrinogen in solution using biophysical methods, revealing internal flexibility and a complex conformational landscape.

Phosphoproteomic mapping reveals distinct signaling actions and activation of protein synthesis and muscle hypertrophy by Isthmin-1

This study identifies distinct phosphoproteomic effects of Ism1 compared to insulin, revealing novel pathways in muscle hypertrophy and protein synthesis.

Conserved epigenetic regulatory logic infers genes governing cell identity

This study introduces a computational method to identify genetic regulators of cell identity using epigenetic data across diverse species and validates findings with CRISPR experiments.

Spatial analysis of ligand-receptor interaction in skin cancer at genome-wide and single-cell resolution

The paper develops a toolbox to study cancer-immune cell communication using multimodal data and a computational method called STRISH, validated on basal and squamous cell carcinomas.

Fine-tuning of Epithelial EGFR signals Supports Coordinated Mammary Gland Development

This study shows that Rasgrp1 fine-tunes EGFR signals in mammary epithelial cells to regulate development during puberty, with in vitro and in vivo effects on proliferation, branching, and cellularity.

Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor associated SPP1+ macrophages and fibroblasts

This paper identifies SPP1+ macrophages and fibroblasts in liver metastatic CRC TME that form immunosuppressive networks, promoting tumor growth and poor prognosis.

DIFFERENTIAL BIOENERGETICS IN ADULT RAT CARDIOMYOCYTES ISOLATED FROM THE RIGHT VERSUS LEFT VENTRICLE

The paper compares bioenergetics in adult rat cardiomyocytes from the right and left ventricle, finding greater maximal respiration and glycolytic rate in right ventricle cells.

Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity

The paper integrates single-cell transcriptomics and chromatin accessibility analysis to identify novel regulatory elements in mouse mammary epithelial cells and their differentiation states.

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

This study identifies unique molecular features of MDSCs using single-cell transcriptomics, revealing a distinct maturation trajectory and novel surface markers for their detection.

A How-To guide to: Quantitative high-speed video profiling to discriminate between variants of primary ciliary dyskinesia

This paper provides a guide to analyzing ciliary beating waveforms using high-speed video microscopy to distinguish between PCD variants and healthy samples.

Super-resolution Molecular Map of Basal Foot Reveals Novel Cilium in Airway Multiciliated Cells

The paper uses super-resolution imaging to reveal a novel hybrid cilium in airway multiciliated cells and its role as a signaling center.

Detection of HPV E7 transcription at single-cell resolution in epidermis

The paper uses scRNA-seq to detect HPV16-E7 mRNA in mouse keratinocytes, showing its association with gene expression and potential for identifying HPV involvement in cancer.