Negative modulation of macroautophagy by HERPUD1 is counteracted by an increased ER-lysosomal network with impact in drug-induced stress cell survival
G. Vargas, O. H. Cortes, E. N. Arias-Munoz, S. F. Hernandez-Galaz, C. Cerda-Troncoso, L. Hernandez-Torres, A. E. Gonzalez, M. Tatham, H. A. Bustamante, C. E. Retamal, J. Cancino, M. Varas-Godoy, R. T. Hay, A. Rojas-Fernandez, V. A. Cavieres, P. V. Burgos
The paper identifies HERPUD1 as a negative regulator of macroautophagy, showing that its stabilization promotes ER-lysosomal network expansion and enhances cell survival under stress.
bioRxiv · Jun 14, 2021 · PreprintCell Biology