Chemo-sEVs release in cisplatin-resistance ovarian cancer cells are regulated by the lysosomal function
C. Cerda-Troncoso, F. Grünenwald, E. Arias-Munoz, V. A. Cavieres, A. Caceres-Verschae, S. Hernandez, B. Gaete-Ramirez, F. Alvarez-Astudillo, R. A. Acuna, M. Ostrowski, P. V. Burgos, M. Varas-Godoy
This study shows that cisplatin-resistant ovarian cancer cells release chemo-sEVs regulated by lysosomal function, with RAB27A silencing restoring lysosomal function and reducing sEVs secretion.
bioRxiv · Feb 3, 2023 · PreprintCancer Biology