A. Rojas-Fernandez

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

This paper describes the engineering of a PROTAC that uses p97-directed proteolysis to achieve specific substrate degradation without relying on E3 ubiquitin ligases.

PML mutants resistant to arsenic induced degradation fail to generate the appropriate SUMO and ubiquitin signals required for RNF4 and p97 recruitment

The paper investigates arsenic resistance in PML mutants by analyzing SUMO and ubiquitin signaling and their impact on RNF4 and p97 recruitment.

An alpaca-derived nanobody neutralizes the SARS-CoV-2 omicron variant

This paper identifies a nanobody that effectively neutralizes the SARS-CoV-2 Omicron variants BA.1 and BA.2, showing high affinity and pre-clinical promise.

Negative modulation of macroautophagy by HERPUD1 is counteracted by an increased ER-lysosomal network with impact in drug-induced stress cell survival

The paper identifies HERPUD1 as a negative regulator of macroautophagy, showing that its stabilization promotes ER-lysosomal network expansion and enhances cell survival under stress.

Serological Profile Of Specific Antibodies Against Dominant Antigens Of SARS-CoV-2 In Chilean COVID-19 Patients.

The paper evaluates antibody responses against SARS-CoV-2 Spike and Nucleocapsid proteins in Chilean COVID-19 patients using western blot and ELISA, finding higher frequency of anti-N antibodies and comparable sensitivity and specificity between antigens.

SUMOylation regulates protein cargo in Astrocyte-derived small extracellular vesicles

This study investigates how SUMOylation affects protein cargo in astrocyte-derived small extracellular vesicles and shows that it influences the physiological function of target cells.

DHX15 regulates CMTR1-dependent gene expression and cell proliferation

This study identifies DHX15 as a regulator of CMTR1-dependent gene expression and cell proliferation through their interaction and functional interplay in RNA processing.