D. Chowdhury

CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis

The paper identifies a multi-cancer gene expression signature of brain metastasis using scRNA-seq and neural networks, detectable in blood-derived platelets.

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

Next-Gen Profiling of Tumor-resident Stem Cells using Machine learning

This paper introduces OSCORP, a machine learning method that identifies cancer stem cells with 99% accuracy using bulk RNAseq data, revealing CSC states and their clinical and transcriptomic signatures across 22 cancer types.

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering

This study identifies an autoinhibited state of 53BP1 stabilized by small molecule ligands, which shift its conformational equilibrium and inhibit chromatin recruitment.

Methotrexate-modulated talin-dynamics drives cellular mechanical phenotypes via YAP signalling

This study shows methotrexate modulates talin dynamics, affecting YAP signaling and cancer cell mechanical properties through focal adhesion changes.

Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ: explained by strain energy

This study compares the force-regulated chaperone activity of tunnel-associated BiP/ERdj3 and their cytoplasmic homologs DnaK/DnaJ, revealing that BiP/ERdj3 act as foldases under force while DnaK/DnaJ act as holdases.

Pan-cancer Analysis Predicts Kindlin-associated Global Mechanochemical Perturbation

This study analyzes pan-cancer data to show kindlin alterations are associated with poor survival, advanced tumor stages, and synergistic effects with cancer hallmark genes.

Trimethylamine N-oxide (TMAO) enhances substrate mechanical stability probed by single molecule magnetic tweezers

This study investigates how TMAO affects the mechanical stability of proteins using single-molecule magnetic tweezers, finding it increases unfolding force and alters folding kinetics.

Talin-drug interaction reveals a key molecular determinant for biphasic mechanical effect: studied under single-molecule resolution

This study investigates talin-drug interactions using single-molecule techniques, revealing biphasic mechanical effects and mechanistic insights into drug-induced stability changes.

Toxicological Analysis of Poly-Lactide Co-Glycolide Microparticles, Chitosan Nanoparticles and Poly(Anhydride) Nanoparticles in Vero Cell

The paper evaluates the in vitro cytotoxicity of chitosan nanoparticles, poly(anhydride) nanoparticles, and PLG microparticles on Vero cells, finding that PLG microparticles at 1000 g/ml reduced cell viability, while others were safe at lower concentrations.

Optimization of conditions for conjugation of outer membrane vesicles of Salmonella Typhimurium with oral delivery systems using response surface method

The paper optimizes conjugation conditions for Salmonella Typhimurium OMVs with delivery systems to maximize entrapment efficiency using response surface methodology.

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

This paper identifies a druggable metabolic vulnerability in diffuse midline glioma through a CRISPR screen, showing that inhibition of DHODH reduces pyrimidine biosynthesis and extends survival in mouse models.

Metallothionein 3-zinc axis suppresses caspase-11 inflammasome activation and impairs antibacterial immunity

The paper identifies MT3 as a negative regulator of caspase-11 inflammasome activation in macrophages, which suppresses antibacterial immunity.

Leaf Aqueous Extract of Manilkara hexandra influenced Glucose Metabolism in fish: An observation with Labeo rohita Fingerlings as model organism

This study investigates the hypoglycaemic effect of Manilkara hexandra leaf extract on glucose metabolism in Labeo rohita fingerlings by analyzing enzyme activities and serum glucose levels.