L. Itzhaki

Development of Constrained Peptide Inhibitors Targeting an Oncogenic E3 Ubiquitin Ligase

This study develops macrocyclic peptides that inhibit the Skp2-p27 interaction by binding to SCFSkp2/Cks1, reducing cell proliferation in breast cancer cells.

Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a

This paper shows nanobodies stabilize p16INK4a mutants and restore their function by binding to a site distinct from CDK6, enabling ternary complex formation.