Author

Y. S. Tan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. S. Verma· 2 shared A. Chandramohan· 1 shared A. Hsu· 1 shared A. J. Cesare· 1 shared A. MESSING· 1 shared A. P. Sobinoff· 1 shared A. Partridge· 1 shared A. Sadruddin· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

C. S. Verma

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Alexander Disease Protein GFAP Drives Mitochondrial Fission

D. XIONG, L. KONG, Y. S. Tan, F. YUAN, Z. SUN, X. LI, E. ABELLA, A. MESSING, S.-C. Zhang

This study identifies GFAP as a novel mediator of mitochondrial fission by surrounding fission sites and modulating Drp1 recruitment, revealing a new mechanism in mitochondrial plasticity.

bioRxiv · Feb 20, 2024 · PreprintCell Biology

Development of Constrained Peptide Inhibitors Targeting an Oncogenic E3 Ubiquitin Ligase

G. Zenkeviciute, W. Xu, J. Iegre, H. Seki, Y. S. Tan, P. J. Rowling, F. Ferrer, C. S. Verma, D. Spring, H. Laman, L. Itzhaki

This study develops macrocyclic peptides that inhibit the Skp2-p27 interaction by binding to SCFSkp2/Cks1, reducing cell proliferation in breast cancer cells.

bioRxiv · Apr 27, 2023 · PreprintCancer Biology

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

C. B. Nelson, S. Rogers, K. Roychoudhury, Y. S. Tan, C. J. Atkinson, A. P. Sobinoff, C. G. Tomlinson, A. Hsu, R. Lu, E. Dray, M. Haber, J. I. Fletcher, A. J. Cesare, R. S. Hegde, H. A. Pickett

This study identifies PLK1 as a target of EYA4 and EYA1 phosphatases, showing that dephosphorylation of pY445 promotes PLK1 activation and mitosis, with implications for cancer therapy.

bioRxiv · Oct 10, 2022Cell Biology

Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells

M. R. Gujar, Y. Gao, X. Teng, Q. Deng, Y. S. Tan, Y. Toyama, H. Wang

This study identifies a Golgi-dependent pathway involving Arf1 and Sec71 that regulates microtubule growth and reactivates quiescent neural stem cells in Drosophila.

bioRxiv · Aug 22, 2022 · PreprintCell Biology

Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality

S. Kannan, P. G. A. Aronica, S. Ng, D. Thean, Y. Frosi, S. Chee, J. Shimin, T. Y. Yuen, A. Sadruddin, H. Y. K. Kaan, A. Chandramohan, J. H. Wong, Y. S. Tan, F. J. Ferrer, P. Arumugam, , A. Partridge

This paper combines macrocyclization and D-amino acid strategies to create an all-D helical peptide with improved target affinity and cellular activity.

bioRxiv · Sep 12, 2019 · PreprintBiochemistry