C. S. Verma

Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer

This study shows RA signaling promotes luminal identity in prostate progenitors through Foxa1, and identifies a loss-of-function mutation in Foxa1 linked to prostate cancer dedifferentiation.

A coarse-grained model of glycosaminoglycans for biomolecular simulation

This paper develops a coarse-grained model for glycosaminoglycans compatible with Martini forcefields, enabling simulation of their conformational and thermodynamic properties.

Development of Constrained Peptide Inhibitors Targeting an Oncogenic E3 Ubiquitin Ligase

This study develops macrocyclic peptides that inhibit the Skp2-p27 interaction by binding to SCFSkp2/Cks1, reducing cell proliferation in breast cancer cells.

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein

The paper designs and tests stapled peptides that inhibit DAXX, a protein involved in cancer, showing they enter cells and disrupt its interactions with other proteins.

Development of a Novel Peptide Aptamer that Interacts with the eIF4E Capped-mRNA Binding Site using Peptide Epitope Linker Evolution (PELE).

This paper develops a novel peptide aptamer that binds eIF4E's cap-binding site using PELE, showing nanomolar affinity and intracellular function modulation.

Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights from Experimental and Molecular Dynamics Simulations Studies

This study evaluates the synergistic interaction of CaD23 with antibiotics and identifies its membrane-permeabilizing mechanism through experimental and molecular dynamics simulations.

TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling pathway

This study identifies TRAF4 as a tumor suppressor in bladder cancer that promotes BMP/SMAD signaling and inhibits metastasis by targeting SMURF1 for degradation.

Conformational ordering of intrinsically disordered peptides for targeting translation initiation

The paper develops bioactive peptides that modulate eIF4E binding by inducing conformational order in intrinsically disordered regions of eIF4G.

Src activates retrograde membrane traffic through phosphorylation of GBF1

This study identifies how Src kinase promotes retrograde membrane traffic by phosphorylating GBF1, facilitating its interaction with Arf1 and enabling GALNTs relocation from Golgi to ER.

Extending the Martini coarse-grained forcefield to N-glycans

This paper extends the Martini forcefield to model N-glycans by optimizing coarse-grained parameters and validating them against experimental data on lectin binding and solvation properties.

Critical role for cold shock protein YB-1 in cytokinesis

This study identifies YB-1's role in cytokinesis by showing its necessity for microtubule organization and phosphorylation-dependent function.

Structure of a consensus chitin-binding domain revealed by solution NMR

The paper determines the 3D structure of a chitin-binding domain from a squid CBP using NMR, revealing how the R&R motif binds chitin and providing insights for biomimetic material design.

Macrocyclization of an all-D linear peptide improves target affinity and imparts cellular activity: A novel stapled α-helical peptide modality

This paper combines macrocyclization and D-amino acid strategies to create an all-D helical peptide with improved target affinity and cellular activity.

De-risking drug discovery of intracellular targeting peptides: screening strategies to eliminate false-positive hits

This paper identifies false-positive peptide inhibitors of KRas using orthogonal assays and cellular screens, highlighting the need for rigorous validation in drug discovery.