Author

J. A. Endicott

Primary ORCID profile (0000-0003-4868-0116 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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J. A. EndicottiD1 paper · Newcastle University

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

J. R. Ault· 2 shared M. E. Noble· 2 shared M. Salamina· 2 shared M. W. Pastok· 2 shared S. Korolchuk· 2 shared A. Basle· 1 shared B. C. Montefiore· 1 shared D. J. Wood· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersBiochemistry

J. R. Ault

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Author profile →

3 papers

Recent·Most cited

Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

R. J. Rowland, S. Korolchuk, M. Salamina, J. R. Ault, S. Hart, J. P. Turkenberg, J. N. Blaza, M. E. Noble, J. A. Endicott

The paper presents the cryo-EM structure of the CDK2-cyclin A-CDC25A complex, revealing key interactions and suggesting potential binding partners for CDC25A.

bioRxiv · Oct 17, 2023 · PreprintBiochemistry

Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a

O. Burbidge, M. W. Pastok, S. L. Hodder, G. Zenkeviciute, M. E. Noble, J. A. Endicott, L. Itzhaki

This paper shows nanobodies stabilize p16INK4a mutants and restore their function by binding to a site distinct from CDK6, enabling ternary complex formation.

bioRxiv · Jul 1, 2021Biochemistry

Discriminative SKP2 interactions with CDK-cyclin complexes support a cyclin A-specific role in p27KIP1 degradation

M. Salamina, B. C. Montefiore, M. Liu, D. J. Wood, R. Heath, J. R. Ault, L.-Z. Wang, S. Korolchuk, A. Basle, M. W. Pastok, J. Reeks, N. J. Tatum, F. Sobott, S. T. Arold, M. Pagano, , J. A. Endicott

The paper identifies a cyclin A-specific interaction between SKP2 and CDK2-cyclin A complexes that promotes p27KIP1 degradation, distinguishing cyclin A from other G1 cyclins.

bioRxiv · Oct 8, 2020Biochemistry