D. Amador-Noguez

This study shows exogenous butyrate inhibits C. difficile growth by interfering with its own butyrate production and alters virulence gene expression.

This study shows that Listeria monocytogenes uses DHNA-dependent redox homeostasis via Ndh2 for survival and virulence, independent of respiration.

The paper uses metabolomics to show that Toxoplasma gondii manipulates host metabolism via the cN-II enzyme during infection.

This study identifies GlmR as an accessory uridyltransferase essential for Listeria monocytogenes cytosolic survival and virulence by synthesizing UDP-GlcNAc.

This study identifies PGE2 production via COX-2 as a cytosol-dependent innate immune response critical for CD8+ T-cell priming against L. monocytogenes.

This study reconstructs a genome-scale metabolic model of Nitrospira moscoviensis and validates it using proteomics, 13C-tracer, and metabolomic analysis to elucidate its autotrophic and formate metabolism.

This study uses isotope tracing and metabolomics to resolve the central carbon metabolism of an anammox bacterium, revealing discrepancies between genomic predictions and in vivo metabolic fluxes.

The paper investigates the regulatory roles of VosA, VelB, and WetA in asexual spore formation in Aspergillus nidulans using transcriptomic, protein-DNA interaction, and metabolomic analyses.

The paper identifies pGpp as a third alarmone in Bacillus and shows NahA converts (p)ppGpp to pGpp, altering alarmone composition and stress response.

This paper identifies a novel Toxoplasma enzyme that redirects carbon into ribose synthesis, bypassing NADP+ dependency, and highlights its potential as a drug target.

This study demonstrates that acI Actinobacteria can synthesize retinal and assemble functional actinorhodopsins for proton pumping using genomic and heterologous expression analyses.