Author

L. J. Saif

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 11 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 11 Organism:human· 8 Assay:proteomics· 6 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

C. Carlin· 10 shared E. M. Oltz· 10 shared R. J. Gumina· 10 shared S.-L. Liu· 10 shared Y.-M. Zheng· 9 shared P. Qu· 8 shared J. P. Evans· 7 shared G. Lozanski· 6 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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10 shared papersMicrobiology

C. Carlin

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Author profile →

12 papers

Recent·Most cited

Distinct Patterns of SARS-CoV-2 BA.2.87.1 and JN.1 Variants in Immune Evasion, Antigenicity and Cell-Cell Fusion

P. Li, Y. Liu, J. Faraone, C. C. Hsu, M. Chamblee, Y.-M. Zheng, C. Carlin, J. S. Bednash, J. C. Horowitz, R. K. Mallampalli, L. J. Saif, E. M. Oltz, D. Jones, J. Li, R. J. Gumina, S.-L. Liu

This study compares immune evasion, antigenicity, and cell-cell fusion properties of SARS-CoV-2 BA.2.87.1 and JN.1 variants, finding BA.2.87.1 shows less neutralization escape and higher infectivity than JN.1 and XBB.1.5.

bioRxiv · Mar 11, 2024Microbiology

Immune Evasion, Infectivity, and Fusogenicity of SARS-CoV-2 Omicron BA.2.86 and FLip Variants

P. Qu, K. Xu, J. N. Faraone, N. Goodarzi, Y.-M. Zheng, C. Carlin, J. S. Bednash, J. C. Horowitz, R. K. Mallampalli, L. J. Saif, E. M. Oltz, D. Jones, R. J. Gumina, S.-L. Liu

This study compares immune evasion, infectivity, and fusogenicity of SARS-CoV-2 variants BA.2.86 and FLip using neutralization assays and cell-based experiments.

bioRxiv · Sep 11, 2023Microbiology

Immune Evasion and Membrane Fusion of SARS-CoV-2 XBB Subvariants EG.5.1 and XBB.2.3

J. N. Faraone, P. Qu, N. Goodarzi, Y.-M. Zheng, C. Carlin, L. J. Saif, E. M. Oltz, K. Xu, D. Jones, R. J. Gumina, S.-L. Liu

This study evaluates neutralization and fusion activity of SARS-CoV-2 XBB subvariants EG.5.1 and XBB.2.3, showing reduced neutralization by bivalent vaccines and highlighting the need for updated vaccine formulations.

bioRxiv · Aug 30, 2023Immunology

Extraordinary Evasion of Neutralizing Antibody Response by Omicron XBB.1.5, CH.1.1 and CA.3.1 Variants

P. Qu, J. N. Faraone, J. P. Evans, Y.-M. Zheng, C. Carlin, M. Anghelina, P. Stevens, S. Fernandez, D. Jones, G. Lozanski, A. Panchal, L. J. Saif, E. M. Oltz, K. Xu, R. J. Gumina, S.-L. Liu

This study evaluates neutralizing antibody escape by Omicron subvariants XBB.1.5, CH.1.1, and CA.3.1, showing near-complete escape from mRNA vaccines but partial rescue with bivalent boosters.

bioRxiv · Jan 16, 2023 · PreprintMicrobiology

Distinct Neutralizing Antibody Escape of SARS-CoV-2 Omicron Subvariants BQ.1, BQ.1.1, BA.4.6, BF.7 and BA.2.75.2

P. Qu, J. P. Evans, J. Faraone, Y.-M. Zheng, C. Carlin, M. Anghelina, P. Stevens, S. Fernandez, D. Jones, G. Lozanski, A. Panchal, L. J. Saif, E. M. Oltz, K. Xu, R. J. Gumina, S.-L. Liu

This study evaluates neutralization resistance and immune evasion mechanisms of SARS-CoV-2 Omicron subvariants against various sera, identifying key mutations driving resistance.

bioRxiv · Oct 19, 2022 · PreprintMicrobiology

Evasion of Neutralizing Antibody Response by the SARS-CoV-2 BA.2.75 Variant

P. Qu, J. P. Evans, Y.-M. Zheng, C. Carlin, L. J. Saif, E. M. Oltz, K. Xu, R. J. Gumina, S.-L. Liu

This study investigates how the BA.2.75 SARS-CoV-2 variant evades neutralizing antibodies through specific mutations and shows enhanced cell-cell fusion.

bioRxiv · Aug 14, 2022Microbiology

Durability of the Neutralizing Antibody Response to mRNA Booster Vaccination Against SARS-CoV-2 BA.2.12.1 and BA.4/5 Variants

P. QU, J. N. Faraone, J. P. Evans, Y.-M. Zheng, C. Carlin, G. Lozanski, L. J. Saif, E. M. Oltz, R. J. Gumina, S.-L. Liu

This study examines the durability of neutralizing antibody responses to SARS-CoV-2 BA.2.12.1 and BA.4/5 variants after mRNA booster vaccination, finding significant waning but stable responses compared to two-dose immunity.

bioRxiv · Jul 21, 2022 · PreprintMicrobiology

Differential Evasion of Delta and Omicron Immunity and Enhanced Fusogenicity of SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants

P. Qu, J. P. Evans, J. N. Faraone, X. Zou, Y.-M. Zheng, C. Carlin, J. S. Bednash, G. Lozanski, R. K. Mallampalli, L. J. Saif, E. M. Oltz, P. J. Mohler, R. J. Gumina, S.-L. Liu

This study compares the neutralization resistance, infectivity, and fusogenicity of SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 subvariants to other variants and finds increased resistance and fusogenicity linked to L452 mutations.

bioRxiv · May 16, 2022 · PreprintMicrobiology

Neutralization and Stability of SARS-CoV-2 Omicron Variant

Z. Cong, J. P. Evans, P. Qu, J. Faraone, Y.-M. Zheng, C. Carlin, J. S. Bednash, T. Zhou, G. Lozanski, R. Mallampalli, L. J. Saif, E. M. Oltz, P. Mohler, K. Xu, R. J. Gumina, S.-L. Liu

This study investigates the immune evasion and transmissibility of the SARS-CoV-2 Omicron variant, showing significant immune evasion but restored neutralization with booster doses and increased transmissibility due to a more stable spike protein structure.

bioRxiv · Dec 16, 2021 · PreprintMicrobiology

Loss of Neutralizing Antibody Response to mRNA Vaccination against SARS-CoV-2 Variants: Differing Kinetics and Strong Boosting by Breakthrough Infection

J. P. Evans, C. Zeng, C. Carlin, G. Lozanski, L. J. Saif, E. M. Oltz, R. J. Gumina, S.-L. Liu

This study examines the decline of neutralizing antibody responses to SARS-CoV-2 variants after mRNA vaccination and shows that breakthrough infection boosts antibody levels.

bioRxiv · Dec 6, 2021 · PreprintMicrobiology

Heat efficiently inactivates coronaviruses inside vehicles

K. P. Karthigeyan, C. Flanigan, D. J. Machado, A. A. Kiziltas, D. A. Janies, J. Chen, D. Cooke, M. V. Lee, L. J. Saif, S. Henegar, J. Jahnes, D. F. Mielewski, J. J. Kwiek

This study tests heat inactivation of coronaviruses on vehicle surfaces using BCoV as a surrogate for SARS-CoV-2, finding 56°C heat effectively reduces infectivity.

bioRxiv · Sep 8, 2021 · PreprintMicrobiology

A practical PPE decontamination method using warm air and ambient humidity

J. J. Kwiek, C. R. Pickett, C. A. Flanigan, M. V. Lee, L. J. Saif, J. Jahnes, G. Blonder

The paper proposes a low-cost, low-temperature decontamination method for PPE using warm air and ambient humidity to effectively reduce SARS-CoV-2 viral load.

bioRxiv · Nov 12, 2020 · PreprintMicrobiology