Author

L. K. Doolittle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Assay:ChIP-seq· 2

Frequent Co-Authors

B. A. Gibson· 3 shared M. K. Rosen· 3 shared C. Blaukopf· 2 shared D. W. Gerlich· 2 shared C. C. H. Langer· 1 shared G. Narlikar· 1 shared I. J. Finkelstein· 1 shared L. E. Jensen· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersBiophysics

B. A. Gibson

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3 papers

Recent·Most cited

In Diverse Conditions Intrinsic Chromatin Condensates Have Liquid-like Material Properties

B. A. Gibson, C. Blaukopf, T. Lou, L. K. Doolittle, I. J. Finkelstein, G. Narlikar, D. W. Gerlich, M. K. Rosen

This study shows that intrinsic chromatin condensates exhibit liquid-like properties under diverse conditions, challenging previous claims of their solidity.

bioRxiv · Nov 22, 2021 · PreprintBiophysics

A chromatin phase transition protects mitotic chromosomes against microtubule perforation

M. W. G. Schneider, B. A. Gibson, S. Otsuka, M. F. D. Spicer, M. Petrovic, C. Blaukopf, C. C. H. Langer, L. K. Doolittle, M. K. Rosen, D. W. Gerlich

This study shows that global histone deacetylation during mitosis induces a chromatin phase transition that protects chromosomes from microtubule perforation and ensures proper segregation.

bioRxiv · Jul 5, 2021 · PreprintCell Biology

Organization and Regulation of Chromatin by Liquid-Liquid Phase Separation

B. A. Gibson, L. K. Doolittle, L. E. Jensen, N. Gamarra, S. Redding, M. K. Rosen

This study shows that chromatin undergoes liquid-liquid phase separation under physiological conditions, driven by histone tail interactions and modulated by acetylation and H1, leading to genome compaction and organization.

bioRxiv · Jan 18, 2019Biophysics