G. Narlikar

Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.

In Diverse Conditions Intrinsic Chromatin Condensates Have Liquid-like Material Properties

This study shows that intrinsic chromatin condensates exhibit liquid-like properties under diverse conditions, challenging previous claims of their solidity.

ATP hydrolysis coordinates the activities of two motors in a dimeric chromatin remodeling enzyme

The paper studies how ATP hydrolysis coordinates two motors in a dimeric chromatin remodeler to slide a nucleosome directionally.

Histone dynamics within the nucleosome play a critical role in SNF2h-mediated nucleosome sliding

The paper replicates and confirms that histone core dynamics are essential for SNF2h-mediated nucleosome sliding, highlighting the importance of proper experimental design in studying nucleosome dynamics.

Ion counting demonstrates a high electrostatic potential of the nucleosome

The paper measures nucleosome electrostatics and finds it retains a strong negative field despite charge reduction from DNA wrapping.