A chromatin phase transition protects mitotic chromosomes against microtubule perforation
M. W. G. Schneider, B. A. Gibson, S. Otsuka, M. F. D. Spicer, M. Petrovic, C. Blaukopf, C. C. H. Langer, L. K. Doolittle, M. K. Rosen, D. W. Gerlich
This study shows that global histone deacetylation during mitosis induces a chromatin phase transition that protects chromosomes from microtubule perforation and ensures proper segregation.
bioRxiv · Jul 5, 2021 · PreprintCell Biology